Costimulatory Blockade-Induced Allograft Survival Requires Beclin1
نویسندگان
چکیده
منابع مشابه
Differential effects of costimulatory pathway modulation on corneal allograft survival.
PURPOSE T lymphocytes have a central role in allograft rejection. On engagement of the T cell receptor by antigenic peptide-major histocompatibility complex (MHC) complex, a second "costimulatory" signal is critical to full T-cell activation or downregulation. In this study, the effect on corneal allograft survival of modulation of the costimulatory molecules programmed death-1 (PD-1) and induc...
متن کاملImpact of both donor and recipient strains on cardiac allograft survival after blockade of the CD40-CD154 costimulatory pathway.
BACKGROUND The effectiveness of anti-CD154 monoclonal antibodies in prolonging the survival of mouse allografts is dependent on the strain combination. In this report, we examined the impact of the donor and the recipient strains on the success of CD40-CD154 blockade. MATERIALS AND METHODS Cardiac allograft survival was monitored in different donor/recipient strain combinations. Morphometric ...
متن کاملIdentification of gene expression profile in tolerizing murine cardiac allograft by costimulatory blockade.
The induction of specific tolerance would be the ultimate achievement in transplant immunology, but the precise mechanisms of immunologic tolerance remain largely unknown. Here, we investigated global gene expression analysis in tolerizing murine cardiac allografts by means of oligonucleotide microarrays. Tolerance induction was achieved in cardiac allografts from BALB/c to C57BL/6 mice by dail...
متن کاملNo synergy between ATG induction and costimulation blockade induced kidney allograft survival in rhesus monkeys.
BACKGROUND Costimulation blockade with antibodies directed against human CD40 and CD86 leads to prolonged kidney allograft survival in rhesus monkeys, but fails to induce permanent graft acceptance. We have tested whether costimulation blockade is more effective after peripheral T-cell ablation with antithymocyte globulin (ATG), with the aim to remove already primed autoreactive cells present i...
متن کاملIdd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice
OBJECTIVE NOD mice model human type 1 diabetes and are used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. However, costimulation blockade-based tolerance protocols have failed in prolonging islet allograft survival in NOD mice. RESEARCH DESIGN AND METHODS To investigate the underlying mechanisms, we studied the ability of costimulation bl...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2014
ISSN: 1600-6135
DOI: 10.1111/ajt.12610